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84 results

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Page 1
Did you mean lc and necrosis (2,213 results)?
4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells.
Roselli E, Boucher JC, Li G, Kotani H, Spitler K, Reid K, Cervantes EV, Bulliard Y, Tu N, Lee SB, Yu B, Locke FL, Davila ML. Roselli E, et al. J Immunother Cancer. 2021 Oct;9(10):e003354. doi: 10.1136/jitc-2021-003354. J Immunother Cancer. 2021. PMID: 34706886 Free PMC article.
We designed CD19-specific CAR T cells with either 4-1BB or mut06 together with the combination of both and evaluated their immune-phenotype, cytokine secretion, real-time cytotoxic ability and polyfunctionality against CD19-expressing cells. We analyzed lymphocyte-specific protei …
We designed CD19-specific CAR T cells with either 4-1BB or mut06 together with the combination of both and evaluated their immune-phenotype, …
Herpesvirus saimiri.
Fickenscher H, Fleckenstein B. Fickenscher H, et al. Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):545-67. doi: 10.1098/rstb.2000.0780. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11313011 Free PMC article. Review.
In the highly oncogenic subgroup C strains, the two virus genes stpC and tip are transcribed from one bicistronic mRNA and are essential for transformation and leukaemia induction. stpC fulfils the typical criteria of an oncogene; its product interacts with Ras and tumour necr …
In the highly oncogenic subgroup C strains, the two virus genes stpC and tip are transcribed from one bicistronic mRNA and are essential for …
The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas.
Paterson JC, Tedoldi S, Craxton A, Jones M, Hansmann ML, Collins G, Roberton H, Natkunam Y, Pileri S, Campo E, Clark EA, Mason DY, Marafioti T. Paterson JC, et al. Haematologica. 2006 Jun;91(6):772-80. Haematologica. 2006. PMID: 16769579
Human tonsillar B-cell subsets were analyzed by flow cytometry for LCK expression. RESULTS: LCK was detected for the first time in germinal centers and, at lower levels, in mantle zone B cells. The presence of LCK in B cells was confirmed by western blotting. …
Human tonsillar B-cell subsets were analyzed by flow cytometry for LCK expression. RESULTS: LCK was detected for the first tim …
Moderate hyperoxia induces inflammation, apoptosis and necrosis in human umbilical vein endothelial cells: An in-vitro study.
Hafner C, Wu J, Soto-Gonzalez L, Kaun C, Stojkovic S, Wojta J, Tretter V, Markstaller K, Klein KU. Hafner C, et al. Eur J Anaesthesiol. 2017 Mar;34(3):141-149. doi: 10.1097/EJA.0000000000000593. Eur J Anaesthesiol. 2017. PMID: 28146458
RESULTS: Constant hyperoxia and cyclic hyperoxia/anoxia impeded cell growth, reduced viability, triggered a proinflammatory response, proven by IL-6, IL-8 and migration inhibitory factor release, and induced apoptosis and necrosis. The inflammatory and cytotoxicity respons …
RESULTS: Constant hyperoxia and cyclic hyperoxia/anoxia impeded cell growth, reduced viability, triggered a proinflammatory response, proven …
LCK inhibitor attenuates atherosclerosis in ApoE(-/-) mice via regulating T cell differentiation and reverse cholesterol transport.
Liu J, Guo Z, Zhang Y, Wu T, Ma Y, Lai W, Guo Z. Liu J, et al. J Mol Cell Cardiol. 2020 Feb;139:87-97. doi: 10.1016/j.yjmcc.2020.01.003. Epub 2020 Jan 21. J Mol Cell Cardiol. 2020. PMID: 31972265
To investigate the effect of LCK on AS in vivo, we injected the LCK inhibitor, PP2, into ApoE(-/-) mice fed a chow diet or a high-fat diet (HFD). ...We further analysed the plaque contents and found that the accumulation of lipids and macrophages were decreased, whi …
To investigate the effect of LCK on AS in vivo, we injected the LCK inhibitor, PP2, into ApoE(-/-) mice fed a chow diet or a h …
Protein kinase activation and myocardial ischemia/reperfusion injury.
Armstrong SC. Armstrong SC. Cardiovasc Res. 2004 Feb 15;61(3):427-36. doi: 10.1016/j.cardiores.2003.09.031. Cardiovasc Res. 2004. PMID: 14962474 Review.
The literature does not support a role for ischemia/reperfusion in the activation of the tyrosine kinases, Src and Lck, or the translocation and activation of PKC. This review will detail the role of these protein kinases in the onset of myocardial cell death by necrosi …
The literature does not support a role for ischemia/reperfusion in the activation of the tyrosine kinases, Src and Lck, or the transl …
CD3D and CD247 are the molecular targets of septic shock.
Yang Q, Feng Z, Ding D, Kang C. Yang Q, et al. Medicine (Baltimore). 2023 Jul 21;102(29):e34295. doi: 10.1097/MD.0000000000034295. Medicine (Baltimore). 2023. PMID: 37478215 Free PMC article.
PPI networks got 5 core genes. Gene expression heat map showed that 5 core genes (CD247, Lck, cd3e, cd3d, ITK) were lowly expressed in the sepsis shock samples and highly expressed in the normal samples. CTD analysis showed that 5 core genes (CD247, Lck, cd3e, cd3d, …
PPI networks got 5 core genes. Gene expression heat map showed that 5 core genes (CD247, Lck, cd3e, cd3d, ITK) were lowly expressed i …
Arsenic interferes with the signaling transduction pathway of T cell receptor activation by increasing basal and induced phosphorylation of Lck and Fyn in spleen cells.
Soto-Peña GA, Vega L. Soto-Peña GA, et al. Toxicol Appl Pharmacol. 2008 Jul 15;230(2):216-26. doi: 10.1016/j.taap.2008.02.029. Epub 2008 Mar 10. Toxicol Appl Pharmacol. 2008. PMID: 18407307
Arsenic exposure did not modify the proportion of B cells. SMC showed an increased level of phosphorylation of lck and fyn kinases (first kinases associated to TCR complex when activated). Although normal levels of apoptosis were observed on freshly isolated SMC, an increa …
Arsenic exposure did not modify the proportion of B cells. SMC showed an increased level of phosphorylation of lck and fyn kinases (f …
Differences in H3K4me3 and chromatin accessibility contribute to altered T-cell receptor signaling in neonatal naïve CD4 T cells.
Bermick JR, Issuree P, denDekker A, Gallagher KA, Santillan D, Kunkel S, Lukacs N, Schaller M. Bermick JR, et al. Immunol Cell Biol. 2022 Aug;100(7):562-579. doi: 10.1111/imcb.12561. Epub 2022 Jun 20. Immunol Cell Biol. 2022. PMID: 35608955 Free PMC article.
Following initiation of TCR signaling using anti-CD3/anti-CD28 beads, adult naive CD4(+) T cells demonstrated increased CD69, phospho-CD3epsilon and interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma and IL-17A compared with neonatal cells. ...Ad …
Following initiation of TCR signaling using anti-CD3/anti-CD28 beads, adult naive CD4(+) T cells demonstrated increased CD69, phospho-CD3eps …
Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of Schisandra Chinensis Mixture on diabetic nephropathy.
Ma Y, Deng Y, Li N, Dong A, Li H, Chen S, Zhang S, Zhang M. Ma Y, et al. J Ethnopharmacol. 2023 Feb 10;302(Pt A):115768. doi: 10.1016/j.jep.2022.115768. Epub 2022 Oct 22. J Ethnopharmacol. 2023. PMID: 36280016
PPI network results showed that the top 15 protein targets in degree value, VEGFA, JAK2, CSF1R, NOS3, CCR2, CCR5, TLR7, FYN, BTK, LCK, PLAT, NOS2, TEK, MMP1 and MCL1, were identified as hub genes. ...The in vivo experiments confirmed that SM significantly inhibited the ove …
PPI network results showed that the top 15 protein targets in degree value, VEGFA, JAK2, CSF1R, NOS3, CCR2, CCR5, TLR7, FYN, BTK, LCK …
84 results